NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in almost every cell in the body. It takes part in the cell's energy production chain and in some processes related to DNA repair, and tissue levels are known to fall with age. The NAD+ application delivers this molecule as a controlled, slow intravenous infusion spread over a long period. The point of the intravenous route is to give a known dose without depending on how well an oral precursor is absorbed.
When it comes up
Most people who ask about it describe a tiredness that has lasted a long time, a sense of mental slowness, a heavy work schedule or disrupted sleep. Others come after long flights, demanding work periods or a heavy training block. These are complaints, not diagnoses. NAD+ does not treat any disease, and if there is a cause behind the fatigue that needs investigating, that takes priority.
Who it suits and who is assessed more carefully
- Adults in stable general health with no history that rules out an intravenous application can be considered.
- It is not advised during pregnancy or breastfeeding.
- A history of kidney or heart failure, serious liver disease or uncontrolled blood pressure means the plan is reconsidered.
- For anyone on regular medication, blood thinners or many supplements, the list is reviewed item by item for interactions.
- Any previous serious reaction to an intravenous treatment must be mentioned.
Suitability and dose are set by a medical assessment in every case.
How the session runs
Your history comes first: medications, past illnesses and what you are hoping for. Tests are requested if needed. If the plan is appropriate, a fine catheter is placed in an arm vein and the NAD+ is started at a low flow rate. You are asked how you feel in the first few minutes, and if nothing is uncomfortable the rate is adjusted gradually. You rest seated or lying down for the rest of the session, free to use your phone or sleep. When the infusion finishes the catheter is removed and brief pressure is applied to the entry site.
A NAD+ session is noticeably longer than the other infusions offered on the same day. That is because the molecule can feel unpleasant when given quickly. You are asked to plan your day accordingly rather than squeeze it in.
Onset and duration of effect
Some people say they feel more rested the same day or the next; others notice no clear difference. Whether and when anything is felt depends on sleep, diet, and whether something else is going on underneath. For that reason a lasting result should not be expected from a single session, and no outcome is promised. The interval between sessions is planned individually after reviewing how you responded to the first one. Results vary from person to person.
What to pay attention to afterwards
- Drink plenty of water on the day; limiting caffeine and alcohol makes for an easier afternoon.
- Do not come in on an empty stomach, have a light meal beforehand.
- A small bruise or tenderness at the entry site can appear and settles within a few days.
- Avoiding very heavy exercise the same day is generally advised.
- Call the clinic if you notice dizziness, palpitations or anything you did not expect.
Points that are often confused
NAD+ and oral NMN or nicotinamide riboside supplements are not the same thing; those are precursor molecules taken by a different route. NAD+ is not an anti ageing injection, it does not stop ageing and it carries no claim about lifespan. It also does not replace sleep, good nutrition and regular movement. Because a fast infusion can produce chest pressure, nausea or dizziness, the flow rate is deliberately kept low; that is how the treatment works rather than a problem with it. Every plan requires a medical assessment.